Regenerative Cell Therapy is a relatively young medical discipline. It is dedicated to promoting and strengthening the body’s own regenerative potential, aiming to stimulate the regeneration of cells and tissue a. o. in patients with tissue defects, musculoskeletal injuries and certain chronic disorders affecting the cardiovascular or immune systems. In the long run, regenerative cell therapies are considered to be changing the purpose of therapies more into the direction of curing than treating patients.
You likely have heard about ethical and political discussions on cell therapies – however, these were mainly referring to embryonal stem cells. Also, stem cells from bone marrow are widely known in the fight against blood cancer (leukaemias for example).
Adipose-Derived Regenerative Cell Therapy (ADRC), using the cells from the body’s own fat tissue has come into focus in past years: it is easy to access, it has no signs of rejection, and the derived cells have amazing skills to promote the body’s own ability to repair and regenerate.
Fat, described in medical terms as adipose tissue, was known to store energy and fat-soluble vitamins – however, it is as well one of the body's richest and most accessible sources of regenerative cells. Regenerative cells derived from adipose tissue (ADRCs) are a soup of cell types consisting of e.g. mesenchymal (adult) stem cells, vascular endothelial cells, and vascular smooth muscle cells, that can help to create new blood vessels among the grafts.
Orthopaedic surgeons are increasingly using adipose-derived cells as a resource in the treatment of osteoarthritis and related conditions. Same as reconstructive and aesthetic surgeons, who apply regenerative cell therapy meanwhile quite commonly in their clinical practice.
However, there are huge differences in the systems in use and the results achieved.
Traditional fat harvesting and grafting are known to damage delicate cells due to the mechanical procedures used. Processing and isolation of ADRCs from adipose requires profound, special methodology, extensive practical laboratory and clinical experience.
The Cytori Celution® System, with more than a decade of clinical experience, has proven to be a successful clinical cell therapy for reconstructive, aesthetic and orthopaedic conditions.
Other than the mechanically processed adipose tissue (also known as micronized or nano fat) the enzymatic process with the Celution® System supports a minimally invasive and tissue-saving procedure: Careful harvesting of own ADRCs and purifying them to an essence – which is upon re-injected into the target tissue in a concentrated way, provoking the own body’s ability to regenerate and heal damaged or impaired tissue.
The enzymatic isolation process ensures efficient, gentle and reproducible separation of nucleated cells from adipose tissue.
As important as the technology are the specialists around, running the entire process!
The fat harvesting is carefully performed by a highly skilled and experienced physician, “feeding” and observing as well the Celution® System, which purifies the cells in the described way, using specific enzymes. The precious essence is carefully injected locally into the damaged or to be repaired tissue (like into the arthrosis-damaged joints, or other damaged tissue areas) or for the purpose of aesthetic skin and tissue regeneration. This requires the skills and experience of an expert in his/her field! It may benefit certain procedures if part of the purified cells is also systemically applied.
The procedure is minimally invasive, and performed in OR setting. Harvesting, purification, and application - all done in one session and at the point of care - takes 2-3 hours in total. Usually performed in light general anaesthesia.
Outcomes on the viability of nucleated cells, and thus regenerative treatment results, have shown to be far superior to comparable devices or traditional fat grafting procedures. It stands for more predictable outcomes, delivering longer and maximum effect, improving the treated tissue and texture of the skin.
Apart from the already applied procedures in orthopaedics, reconstruction and aesthetic medicine, international studies show as well promising results in other medical treatment fields like systemic scleroderma, heart diseases, andrology diseases, fistulas and chronic wounds.
The ADRC-Therapy is available in selected medical centres only. Contact us for more information.
A chronic wound does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do. Wounds that do not heal adequately within 4 weeks are considered chronic. Previous wound healing disorders are often resulting from poor blood circulation, like arterial or venous ulcers, or as a complication in Diabetes Mellitus – like the Diabetic Foot Syndrom. Frequently, chronic wounds are derived from bedsores or leg ulcers, but also surgical wounds can become chronic. Infected wounds have an 85% chance to develop into the chronic wound. Chronic, non-healing wounds affect millions of people worldwide, with massive consequences on their quality of life.
A thin layer of biofilm (made up of actively multiplying bacteria) adheres to the lesion and results in recurring infections. The defect worsens, delaying the healing process to the point that the wound becomes chronic.
For an acute wound to heal, the balance between inflammation and tissue regeneration needs to be restored. But 80% of wounds do not heal due to infection. A biofilm, formed by multiplying bacteria, keeps the infection alive.
Current methods fail to penetrate the biofilm and thereby eliminate the bacteria. So far, major surgical debridement is advised as an effective therapy, often under general anaesthesia. Stressful for the patient, and not always with satisfying results (as biofilm is not visible to the human eye), why the procedure often has to be repeated multiple times.
With proper diagnosis and treatment, much of the above-mentioned burden can be avoided. Recent innovations in the field of wound healing have created a number of advanced therapies, from which clinicians can now choose. Critical to successful outcomes is, that the wound bed is cleaned and made free of bacteria that cause the infection.
We are pleased to offer the world’s first effective method to battle infected chronic wounds within our expert network.
Simple – Fast - Safe.
Experienced physicians, specialising in wound management, are applying a desiccant gel, that rapidly disrupts the infection causing biofilm, pathogens and inflammatory proteins in the wound – thus turning chronic wounds into acute wounds. It is a unique method for a simple, non-surgical debridement, followed by cleaning and dressing. Where needed, local anaesthesia can be considered. The unique one-time-treatment is completed within a short time and can be performed in outpatient clinics, specialized wound centres or in hospitals.
This new debridement concept, debrides the wound bed chemically instead of surgically, by a one-time application of up to 60 seconds only!
The biofilm and the residing infection are all addressed within this one application - and the wound healing process starts. The product (gel) is applied directly to the wound bed, rinsed off, and the wound is bandaged upon the doctor's choice.
Clinical case studies revealed ground-breaking results in its ability to eliminate the infection inside a chronic wound completely. Patients, with no healing progress for 6 to 12 months, started to develop clear signs of healing. In a few very severe cases, the application had to be repeated.
Note! This unique treatment is solely offered in highly specialized wound centres!. Please request the most appropriate centre for your requirements. To initiate, please connect to our case managers by clicking here: Contact us
The German hospitals and German clinics in our network offer a broad spectrum of medical treatments. Our specialty areas include treatments such as orthopedics, spine, heart and vascular surgery. The medical treatments listed on our website is just a small selection of all the medical treatments available in Germany.
Every patient and every medical treatment request is unique and needs a personalised approach. Contact us with your individual request and you will receive a personalised approach on your medical requirement. Please fill in the enquiry form or give us a call. We are also available to chat during office times.
German doctors will use advanced diagnostic and imaging technology to get an accurate picture of your health. This includes detecting conditions which may not apparent from an external physical examination alone.
Our checkup programs always include:
Extra modules (sometimes standard, dependent on clinic):
Contact us for more information on medical check-ups and diagnosis in Germany.